??????骞翠?甯?锛??ㄧ??棣?涓???楠ㄥ?宠???????骞茬??????╁凡绾冲?ユ?拌???宠?

?????瑰??瀹癸?2021骞???23?ワ??╁?戒?涓???绌跺?㈤??瀹ｅ?锛??跺??????ㄧ??棣?娆惧??娆?strong>?宠????娉ㄥ?娌荤??涓ラ??楠ㄥ?宠?????????骞茬???????/strong>姝ｅ????烘?拌???宠?锛?NDA锛?锛?璇ヨ??互??Jointstem???藉?????宠??ラ『?╋???????2022骞村?ㄩ?╁?借?锋?逛?甯???

????楠ㄥ?宠??????娌荤????娈典富瑕????????┿?????┿????????规?锛?浣??变?杞????????涓??????э?楠ㄥ?宠?????句互娌绘??锛?涓??存???版?板?荤?????ｈ?????鹃???杩?骞存?ワ??????????诲???????绐??存?ц?灞?锛?骞茬???娌荤??楠ㄥ?宠??????涓虹??绌舵?扮???瑰???伴???┿??

01?????????共缁???娌荤?????宠??楠ㄥ?宠????

2021骞???17?ワ??ㄧ??棣?涓?娇?ㄨ????????村??璐ㄥ共缁???娌荤??涓ラ?????宠??楠ㄥ?宠??????骞茬???3??涓村?璇?楠??ㄩ?╁?藉??寰???????璇ヨ???╃??3??涓村???绌惰〃??锛?瀹????瑰?????宠?????姐????杞荤?肩??锛?骞跺???????宠??杞????

????锛?JointStem???????ㄦ???胯揪16骞达?浠?2005骞村?濮?锛????剁??????稿凡??璧??板??涓?缇????ㄤ???????????璇ヨ???╁凡缁?杩?琛?浜?1??2??锛?2008骞磋?锋?癸???2b??锛?2014骞磋?锋?癸???3??涓村?璇?楠?锛?骞舵坊??浜?瀵逛???2b??涓村?璇?楠???璺?韪???绌躲??

璇ョ??绌剁??绗??舵?浜?2019骞????峰??╁?芥?瑰??锛??????涓?搴???澶у??婚?㈠?ㄥ????????13瀹跺?婚?㈠???诲??strong>252???ｈ??????浜?3??涓村?璇?楠????ㄧ??斤?2??涓村?璇?楠?宸茶?峰?缇??介??????????ｇ???灞????瑰??骞舵????瀹??姐??

3??涓村?璇?楠?锛?涓昏???瀵?ellgren-Lawrence (KL) 3绾ч?????ｈ??杩?琛???涓村?璇?楠???涓昏???????‘璁よ???骞茬???娉ㄥ?娑茬?ㄤ???杞婚??宠?????肩?????瑰?????宠??杞?????界??瀹??ㄦ?у???????с??瀹??板?????╂??ǔ瀹??????琛?娓????ヨ? JointStem ????诞??????姘寸??娣峰???╋?涓?????????????村??璐ㄥ共缁?????

WOMAC锛?楠ㄥ?宠???????帮??? VAS锛??肩?????帮?琚??ㄤ?涓昏?璇?浼板??????杩?涓ら」???颁?娉ㄥ??????虹嚎璇???锛??版敞灏?24?ㄥ????杈?楂?璇?????骞茬???缁?涓?瀹??板??缁??告?锛?璇ヨ???????杈?澶э??锋??缁?璁″???涔???

?朵?娆¤?璇?浼板????? WOMAC 浜?缁?锛??肩?????电‖???ュ父??娲昏?浼板?伴?撅???KOOS 璇?浼帮????宠????浼ゅ??楠ㄥ?宠????缁???璇???锛??? SF-36锛???娲昏川??璇?浼帮???X 灏?绾裤??MRI ??杩?璇?浼颁?浣跨?ㄩ??????????????澶╂?般??WOMAC浜?缁???????璇?浠疯???锛??肩?????电‖???ュ父??娲诲?伴?撅??????虫??缁?璁″???涔???杈?浣?璇?????

瀵逛?璇?浼扮??娲昏川????SF-36锛?骞茬???娉ㄥ?缁???韬???ュ悍璇?????蹇????ュ悍璇??????剧??澧???锛?娌荤??????涔??剧ず?虹?璁″?涓????剧???瑰??锛?姣?涓???0.0084??0.0038锛????ㄤ?璇?浼拌???宠?????藉??娲诲?ㄨ?浼扮?? IKDC 璇???? JointStem 娉ㄥ?缁?涓???撮?锛?娌荤???????剧ず?虹?璁″??剧???瑰??锛?p<0.0001锛???

浠? X 绾胯?浼版?ョ??锛?骞茬???娉ㄥ?缁???3???ｈ??浠? KL3 绾ф?瑰????绾э?2 ???ｈ??锛???浠? KL4绾ф?瑰????绾э?1 ???ｈ??锛?锛?104???ｈ??淇???涓?骞茬???娉ㄥ????稿????绛?绾с???惰??锛?瀹??板??娉ㄥ?缁?涓?病???ｈ???虹?版?瑰????

MRI?????剧ず骞茬???娉ㄥ?缁?锛??????渚у??WB?￠???渚ц蒋楠ㄧ己??娣卞害??杞??缂烘??琛ㄩ?㈠ぇ灏???楠ㄩ????跺ぇ灏???杞??涓?纾ㄦ????杞??涓????垮ぇ灏???杞?????跨???伴????姣?渚?寰??版?瑰????淇?????

缁?璇?瀹?锛?骞茬???娉ㄥ?缁??ｈ?????ㄧ?稿?????????╃??澶╂?板?????╂?诲??????灏?浜?瀹??板??娉ㄥ?缁???涓ょ?涔??寸??姣?杈??剧ず?虹?璁″?涓????剧??宸??锛?姣?涓???0.0338??0.0008锛?锛???姝ょ??绌惰?瀹?骞茬???娉ㄥ?????灏?浜??ｈ?????ㄩ????????澶╂?板?????╃???诲??????

瀵逛?瀹??ㄦ?у????锛?娌℃??涓?骞茬????稿?崇????澶т????浠躲????008骞村?濮?涓村?璇?楠?浠ユ?ワ????虹?颁????ㄥ共缁????稿?崇???跨?ょ??渚???

02??骞茬???娌荤??楠ㄥ?宠????瀹??ㄦ????

?????????诲?????????灞?锛?骞茬????????剁?存?ュ???????????????????绛??规?у?ㄨ??楠ㄥ?宠????娌荤??涓???????瑕??颁???

骞茬???浣?涓轰?绉??峰?楂?搴﹀?????藉????缁???锛??藉?淇??浜轰?????绉?缁?缁?锛??瑰???????楠ㄥ?宠??淇????杞??????????浼ゅ??????绛??归???瀹??藉?ㄤ???寰????浣??ㄤ?涓诲?ㄨ?绉昏?冲?????ㄤ?杩?琛?淇????寤猴?淇?杩???????杞???????????讹?瀹???互??娉?澶?绉??锋??璋?????????????浣??ㄧ??缁?????瀛?锛??ョ?瑙ｉ??宠??????涓村????讹?涓轰??规???娌绘??楠ㄥ?宠??????渚?浜????姐??

浼?澶????藉??澶?涓村?璇?楠?琛ㄦ??锛?骞茬?????娉?娌荤??楠ㄥ?宠????瀹??ㄦ??????骞茬???宸茬???涓烘不??楠ㄥ?宠????????甯????????????????╀?涓???

????锛??规???藉????????ｇ???灞?(NMPA)?剧ず锛??辨??3娆?/strong>??瀵硅??楠ㄥ?宠??????骞茬????拌???峰?涓村??逛欢????娆″?绀轰?骞茬????ㄩ??宠????棰?????涓村?搴??ㄥ??????

杩??ㄨ???????共缁???娌荤???????у?宠????搴??ㄨ??ヨ?????锛??????瓒??ヨ???????杩?椤规??????互璁╂?╂????涓????ｈ???????宠?????伴?垮?哄??杞??缁???锛?浣垮??????у?宠??????涓哄???????剧????

缁间???杩?/strong>锛?骞茬????????诲?????灞?涓轰汉绫绘?????村????炬?ｆ??渚?浜??村??????芥?э??镐俊??Jointstem?????╁?????澶?骞茬????????????朵腑涔?涓?锛??ㄦ???ワ?灏?浼???瓒??ヨ?澶????存??????骞茬??????╂?ュ府?╃?颁唬?诲?????灞?锛?涓哄箍澶ф?ｈ??甯︽?ョ??炽??